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. 2025 Sep 3;23:507–524. doi: 10.3290/j.ohpd.c_2258

Table 5.

Comprehensive comparison of treatment strategies for different epulis subtypes. This table provides a consolidated overview of first-line treatments, surgical considerations, alternative therapeutic approaches, and special management considerations for fibrous epulis, vascular epulis, pregnancy epulis, and giant cell epulis. Each column highlights both common approaches and subtype-specific treatment modalities that are essential for optimal clinical management.

Treatment approach

Fibrous epulis

Vascular epulis

Pregnancy epulis

Giant cell epulis

First-line treatment

Surgical excision with 2 mm margins

Surgical excision with 2 mm margins

Conservative management until postpartum if possible

Surgical excision with curettage or peripheral ostectomy

Surgical considerations

Standard excision including periosteum

Removal of underlying causes; control bleeding

Defer surgery until 2nd trimester if needed; possible postpartum resolution

Deep excision including periodontal ligament

Laser therapy Options

Diode, CO2, Er:YAG, Nd:YAG lasers

Diode, CO2, Er:YAG, Nd:YAG, pulsed dye lasers

Nd:YAG laser preferred during pregnancy

Diode laser, high-level laser therapy

Minimally invasive alternatives

May regress with removal of irritants in early lesions

Scaling and root planing for small lesions

Basic periodontal treatment; observation

Ethanolamine oleate sclerotherapy

Sclerotherapy

Not typically used

Pingyangmycin, ethanol, ethanolamine oleate, sodium tetradecyl sulphate

Not recommended during pregnancy

Limited evidence for effectiveness

Adjunctive treatments

Corticosteroid injection for recurrent cases

Corticosteroid injection for recurrent cases

Not recommended during pregnancy

Calcitonin, α-interferon in select cases

Management of defects

CAF, CRF, SCTG, LPF, or PRF for large defects

CAF, SCTG, LPF for aesthetic areas

Defer reconstruction until postpartum

CAF, SCTG for large defects

Recurrence management

Re-excision; elimination of irritants

Re-excision with wider margins; sclerotherapy

May recur in subsequent pregnancies

Re-excision with peripheral ostectomy

Special considerations

Lower recurrence rate than other types

Higher bleeding risk during excision

Balance maternal oral health with foetal safety

More aggressive behaviour; bone involvement