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. 2025 Aug 28;17(17):2811. doi: 10.3390/cancers17172811
BTC biliary tract cancer
ICI immune-checkpoint inhibitors
iCCA intrahepatic cholangiocarcinoma
eCCA extrahepatic cholangiocarcinoma
GB gallbladder cancer
CCA cholangiocarcinoma
FDG-PET 18F-2-fluoro-2-deoxy-d-glucose-positron emission tomography
OS overall survival
PD-1/PDL-1 programmed cell death protein-1/ligand-1
MSI microsatellite instability
TMB tumor mutational burden
TME tumor microenvironment
FDA food and drug administration
PFS progression-free survival
TP53 tumor protein p53
BRCA2 breast cancer gene
Chemo-IO chemo-immunotherapy
KRAS Kirsten rat sarcoma
ARID1 at-rich interaction domain 1A
CTLA-4 cytotoxic T-lymphocyte antigen-4
ctDNA circulating tumor DNA
ORR overall response rate
CPS combined positive score
DCR disease control rate
IDH1 isocitrate dehydrogenase 1
FGFR2 fibroblast growth factor receptor 2
MAPK mitogen-activated protein kinase
MEK methyl ethyl ketone
BRAF B-Raf-proto-oncogene
Her2 Human epidermal growth factor receptor 2
RTK receptor tyrosine kinase
PARPi Poly (ADP-ribose) polymerase inhibitors
PR partial response
VEFG vascular endothelial growth factor
APC antigen-presenting cells
TIM3 T-cell immunoglobulin and mucin domain-3
LAG4 lymphocyte-activation gene 3
RFS relapse-free survival
CEA carcinoma embryonic antigen