Algorithm 1 Image Preprocessing Pipeline

1:procedure PreprocessImage(I) 2:      $I_{\mathrm{resized}}\leftarrow \mathrm{Rescale}(I,M,N)$ 3:      $I_{\mathrm{norm}}\leftarrow \mathrm{Normalize}\left(I_{\mathrm{resized}}\right)$ 4:      $I_{\mathrm{smooth}}\leftarrow \mathrm{GaussianFilter}(I_{\mathrm{norm}},\sigma )$ 5:      $I_{\mathrm{aligned}}\leftarrow \mathrm{RegisterImage}(I_{\mathrm{smooth}},\mathrm{reference})$ 6:      return $I_{\mathrm{aligned}}$