ACC	Anterior Cingulate Cortex
BDNF	Brain-Derived Neurotrophic Factor
CALCA	Calcitonin Gene-Related Peptide Alpha
cAMP	Cyclic Adenosine Monophosphate
CCL2	C-C Motif Chemokine Ligand 2
CGRP	Calcitonin Gene-Related Peptide
CLR	Calcitonin Receptor-Like Receptor
CNS	Central Nervous System
CPM	Conditioned Pain Modulation
CRPS	Complex Regional Pain Syndrome
CSF	Cerebrospinal Fluid
CXCL1	C-X-C Motif Chemokine Ligand 1
CX3CL1	C-X3-C Motif Chemokine Ligand 1
CX3CR1	C-X3-C Motif Chemokine Receptor 1
DNIC	Diffuse Noxious Inhibitory Control
DMN	Default Mode Network
DRG	Dorsal Root Ganglion
EMA	European Medicines Agency
FDA	Food and Drug Administration
fMRI	Functional Magnetic Resonance Imaging
GABA	Gamma-Aminobutyric Acid
5-HT	5-Hydroxytryptamine (Serotonin)
IL-1β	Interleukin-1 Beta
IL-6	Interleukin-6
IL-10	Interleukin-10
IL-12	Interleukin-12
IL-23	Interleukin-23
iNOS	Inducible Nitric Oxide Synthase
KCC2	Potassium-Chloride Co-transporter 2
LTP	Long-Term Potentiation
mPFC	Medial Prefrontal Cortex
MyD88	Myeloid Differentiation Primary Response 88
NAc	Nucleus Accumbens
NE	Norepinephrine
NF-κB	Nuclear Factor Kappa B
NK1	Neurokinin-1
NLRP3	NLR Family Pyrin Domain Containing 3
NMDA	N-methyl-D-aspartate
NNT	Number Needed to Treat
P2X7	P2X Purinoceptor 7
PAG	Periaqueductal Gray
PBMCs	Peripheral Blood Mononuclear Cells
PET	Positron Emission Tomography
PNS	Peripheral Nervous System
PRISMA	Preferred Reporting Items for Systematic Reviews and Meta-Analyses
QST	Quantitative Sensory Testing
RAMP1	Receptor Activity-Modifying Protein 1
RCP	Receptor Component Protein
RCTs	Randomized Controlled Trials
RNA	Ribonucleic Acid
RVM	Rostral Ventromedial Medulla
SANRA	Scale for the Assessment of Narrative Review Articles
SCN9A	Sodium Voltage-Gated Channel Alpha Subunit 9
scRNA-seq	Single-Cell RNA Sequencing
SNRIs	Serotonin-Norepinephrine Reuptake Inhibitors
TAC1	Tachykinin Precursor 1
TGF-β	Transforming Growth Factor Beta
TLR4	Toll-Like Receptor 4
TNF-α	Tumor Necrosis Factor Alpha
TrkB	Tropomyosin Receptor Kinase B
TRPV1	Transient Receptor Potential Vanilloid 1
TSPO	Translocator Protein
VTA	Ventral Tegmental Area
WoS	Web of Science