| AAV5 | Adeno-Associated Virus 5 |
| ACSF | Artificial cerebrospinal fluid |
| ATP | Adenosine triphosphate |
| CA1 | Cornu Ammonis 1 |
| CA3 | Cornu Ammonis 3 |
| CNO | Clozapine N-oxide |
| CP | Corner point |
| DEGs | Differentially expressed genes |
| DG | Dentate gyrus |
| DREADD | Designed Receptor Exclusively Activated by Designer Drugs |
| DS | Down syndrome |
| EPSCs | Excitatory postsynaptic currents |
| FANS | Fluorescence-Activated Nuclear Sorting |
| HSA21 | Homo Sapiens Autosome 21 |
| iPSCs | Induced pluripotent stem cells |
| NA | Numerical aperture |
| NGS | Normal Goat Serum |
| OD | Optical Disector |
| PBS | Phosphate-Buffered Saline |
| PFA | Paraformaldehyde |
| ROI | Region of interest |
| SC | Schaffer collaterals |
| UMAP | Uniform Manifold Approximation and Projection |
| UMI | Unique Molecular Identifier |
| WT | Wild type |