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. 2025 Sep 12;11(37):eadr6684. doi: 10.1126/sciadv.adr6684

Table 1. Demographics of the birth cohort, including births from 23 October 2010 to 24 October 2019.

Limited to singletons, excluded implausible birthweight and gestation lengths, and those missing maternal zip code. General inclusion criteria: birthweight of >500 and <6800 g, birth week of >20 and <45, zip code provided, and singleton.

Covariate Category Exposed Aliso communities Los Angeles County Matched control communities (tracts) Statewide urban
10-km buffer south of SS-25 Excluding exposed Excluding exposed Excluding exposed
n = 13,848 n = 1,056,901 n = 20,196 n = 3,812,896
n (%) or means ± SD n (%) or means ± SD n (%) or means ± SD n (%) or means ± SD
Maternal age Means ± SD 31.1 ± 5.6 29.6 ± 6.2 31.0 ± 5.5 29.5 ± 6.1
<20 349 (2.5) 57,658 (5.5) 488 (2.4) 198,914 (5.2)
20–25 1933 (14.0) 230,905 (21.8) 2729 (13.5) 846,230 (22.2)
26–30 3726 (26.9) 281,060 (26.6) 5732 (28.4) 1,059,926 (27.8)
31–35 4784 (34.5) 294,809 (27.9) 7056 (34.9) 1,071,463 (28.1)
36+ 3056 (22.1) 192,461 (18.2) 4190 (20.7) 636,317 (16.7)
Maternal race/ethnicity Hispanic, any race 5050 (36.5) 598,383 (56.6) 6215 (30.8) 1,812,731 (47.5)
White, non-Hispanic 5003 (36.1) 197,266 (18.7) 10,923 (54.1) 1,027,095 (26.9)
Black, non-Hispanic 602 (4.3) 77,199 (7.3) 209 (1.0) 220,158 (5.8)
Asian/Pacific Islander, non-Hispanic 2905 (21) 165,169 (15.6) 2499 (12.4) 623,026 (16.3)
Other/unknown 288 (2.1) 18,884 (1.8) 350 (1.7) 129,886 (3.4)
Maternal education Mean of ordinal ranks (0–8)* 5.1 ± 1.8 4.2 ± 2 5.0 ± 1.9 4.4 ± 2
Baby’s sex Male 7101 (51.3) 542,231 (51.3) 10,439 (51.7) 1,954,758 (51.3)
Female 6747 (48.7) 514,663 (48.7) 9757 (48.3) 1,858,113 (48.7)
Parity 1st 6058 (43.7) 431,021 (40.8) 8236 (40.8) 1,527,460 (40.1)
2nd 4908 (35.4) 337,616 (31.9) 7388 (36.6) 1,225,554 (32.1)
3rd 1981 (14.3) 170,827 (16.2) 3131 (15.5) 624,840 (16.4)
4+ 901 (6.5) 117,437 (11.1) 1441 (7.1) 435,042 (11.4)
Prenatal care No 23 (0.2) 3873 (0.4) 32 (0.2) 19,744 (0.5)
Yes 13,825 (99.8) 1,053,028 (99.6) 20,164 (99.8) 3,793,152 (99.5)
Season of birth Fall 3553 (25.7) 273,320 (25.9) 5192 (25.7) 974,949 (25.6)
Winter 3418 (24.7) 252,749 (23.9) 5077 (25.1) 925,952 (24.3)
Spring 3649 (26.4) 275,830 (26.1) 5126 (25.4) 999,264 (26.2)
Summer 3228 (23.3) 255,002 (24.1) 4801 (23.8) 912,731 (23.9)
Adverse birth outcomes LBW 868 (6.3) 65,890 (6.2) 1106 (5.5) 229,020 (6.0)
TLBW 320 (2.5) 23,836 (2.5) 351 (1.9) 81,120 (2.3)
Preterm 1162 (8.4) 92,253 (8.7) 1466 (7.3) 314,990 (8.3)
*

0, no formal education; 1, eight grade or less; 2, 9th grade through 12th grade–no diploma; 3, high school graduate or GED completed; 4, some college credit–no degree; 5, associate degree; 6, bachelor’s degree; 7, master’s degree; 8, doctorate or professional degree.