1KGP	The 1000 Genomes Project
AMPH1	Amphiphysin1
ARHGEF2	Rho guanine nucleotide exchange factor 2
CACNA1E/Cav2.3	Voltage-dependent R-type calcium channel subunit alpha-1E (Cav2.3)
CDD	CDKL5 Deficiency Disorder
CDKL5	Cyclin-Dependent Kinase-Like 5
CEP131	Centrosomal protein of 131 kDa
CVI	Cortical/cerebral visual impairment
DLG5	Disks large homolog 5
DNMT1	DNA methyltransferase 1
EB2/MAPRE2	Microtubule-associated protein RP/EB family member 2
ELOA	Elongin A
EP400	EE1A-binding protein p400
GATAD2A	GATA zinc finger domain containing 2A
GRCh38	The Genome Reference Consortium Human Build 38
GTF2I	General transcription factor II-I
HDAC4	Histone deacetylase 4
IGSR	The International Genome Sample Resource
IQGAP1	IQ Motif Containing GTPase Activating Protein 1
MAP1S	Microtubule-associated protein 1S
MeCP2	Methyl-CpG binding protein 2
NGL-1/KIAA1580/LRRC4C	Netrin-G ligand-1
OMIM	Online Mendelian Inheritance in Man
PPP1R35	Protein phosphatase 1 regulatory subunit 35
PSD95/DLG4	Postsynaptic density protein 95
SHTN1/SHOT1	Shootin1
SMAD3	Mothers against decapentaplegic homolog 3
SOX9	Transcription factor SOX-9
SQSTM1/p62	Sequestosome-1(p62)
STK9	Serine threonine kinase 9
TTDN1	TTD non-photosensitive 1 protein
VDW	Van der Waals
XCI	X-chromosome inactivation
ZNF219	Zinc finger protein 219
ΔΔGbinding	Binding free energy change
ΔΔGfolding	Folding free energy changes
ΔΔGBmax	Maximum binding free energy change: For each variant, the maximum complex-averaged |ΔΔGbinding| across selected CDKL5-target protein–protein interactions.
ΔΔGFmax	Maximum folding free energy change: For each variant, the highest ΔΔGfolding value across several computational methods.