Table 1.

Candidate CDKL5 binding partners with consensus motif.

SL	UniProt	Gene	pSite	Consensus Motif (RPX[S/T][A/G/P/S])	Protein	Evidence	Source
1	Q92974	ARHGEF2	S122	TIRERPSsAIYPS	Rho guanine nucleotide exchange factor 2	Motif and biochemical	[32]
2	P49418	AMPH1	S293	PAPARPRsPSQTR	Amphiphysin1	Motif and biochemical	[32]
3	Q9UPN4	CEP131	S35	PVSRRPGsAATTK	Centrosomal protein of 131 kDa	Motif and biochemical	[32]
4	Q8TDM6	DLG5	S1115	QKRRRPKsAPSFR	Disks large homolog 5	Motif and biochemical	[32]
5	Q14241	ELOA	S311	EENRRPPsGDNAR	Elongin A	Motif and biochemical	[32]
6	Q96L91	EP400	S729	SPVNRPSsATNKA	EE1A-binding protein p400	Motif and biochemical	[32]
7	Q66K74	MAP1S	S871, S900	KAPARPSsASATP, DRASRPLsARSEP	Microtubule-associated protein 1S	Motif and biochemical	[32]
8	Q15555	EB2/MAPRE2	S222	STPSRPSsAKRAS	Microtubule-associated protein RP/EB family member 2	Motif and biochemical	[32]
9	Q8TAP9	TTDN1	S40	GGGPRPPsPRDGY	TTD non-photosensitive 1 protein	Motif and biochemical	[32]
10	P26358	DNMT1		N/A	DNA methyltransferase 1	Biochemical	[32]
11	P56524	HDAC4	S632	RPLSRAQsSPASAtF	Histone deacetylase 4	Motif and biochemical	[32]
12	Q9HCJ2	NGL-1/KIAA1580/LRRC4C	S631	PLLIRMNsKDNVQET	Netrin-G ligand-1	Motif and biochemical	[32]
13	P84022	SMAD3	N/A	N/A	Mothers against decapentaplegic homolog 3	Biochemical	[32]
14	P48436	SOX9	S199	ATEQTHIsPNAIFKA	Transcription factor SOX-9	Biochemical	[32]
15	P46940	IQGAP1	N/A	N/A	IQ Motif Containing GTPase Activating Protein 1	Biochemical	[32]
16	P51608	MeCP2	N/A	N/A	Methyl-CpG binding protein 2	Biochemical	[32]
17	P78352	PSD95/DLG4	N/A	N/A	Postsynaptic density protein 95	Biochemical	[32]
18	A0MZ66	SHTN1/SHOT1	N/A	N/A	Shootin1	Biochemical	[32]
19	P78347	GTF2I	S674	QSPKRPRsPGSNS	General transcription factor II-I	Motif and biochemical	[42]
20	Q8TAP8	PPP1R35	S52	SLSPRPDsPQPRH	Protein phosphatase 1 regulatory subunit 35	Motif and biochemical	[42]
21	Q86YP4	GATAD2A	S100	KSERRPPsPDVIV	GATA zinc finger domain containing 2A	Motif and biochemical	[42]
22	Q9P2Y4	ZNF219	S114	HQPERPRsPAARL	Zinc finger protein 219	Motif and biochemical	[42]
23	Q15878	CACNA1E/Cav2.3	S14	AVVARPGsGDGD	Voltage-dependent R-type calcium channel subunit alpha-1E (Cav2.3)	Motif and biochemical	[62]
24	Q13501	SQSTM1/p62	T269/S272	RSRLTPVsPESS, GGKRSRLtPVSP	Sequestosome-1(p62)	Biochemical	[63]

These data were compiled from the following literature: [32,41,42]. N/A: Not Available.