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. 2025 Sep 1;26(17):8488. doi: 10.3390/ijms26178488
A. muciniphila Akkermansia muciniphila
ABCA1 ATP-binding cassette transporter A1
ABCG2 ATP-binding cassette super-family G member 2
ACC Acetyl-CoA carboxylase
Akt Protein kinase B (also part of PI3K-Akt pathway)
AMPK AMP-activated protein kinase
ApoA-I Apolipoprotein A-I
ApoE Apolipoprotein E
AS Atherosclerosis
ASBT Apical sodium-dependent bile acid transporter
ASCVD Atherosclerotic cardiovascular disease
ATG16L1 Autophagy related 16 like 1
B. uniformis Bacteroides uniformis
bai Bile acid-inducible (operon)
BARs Bile acid receptors
BAs Bile acids
B-GOS Bifidobacterial-galacto-oligosaccharides
BSH Bile salt hydrolase
CA Cholic acid
CAR Constitutive androstane receptor
CD14 Cluster of differentiation 14
CD204 Cluster of differentiation 204
CD36 Cluster of differentiation 36
CDCA Chenodeoxycholic acid
COX-2 Cyclooxygenase-2
COVID-19 Coronavirus disease 2019
CRC Colorectal cancer
CVD Cardiovascular disease
CYP27A1 Cytochrome P450 family 27 subfamily A member 1
CYP7A1 Cytochrome P450 family 7 subfamily A member 1
CYP7B1 Cytochrome P450 family 7 subfamily B member 1
DCA Deoxycholic acid
DCs Dendritic cells
DIP Dictyophora indusiata polysaccharide
DMB 3,3-dimethyl-1-butanol
E. coli Escherichia coli
EDH Endothelium-derived hyperpolarization
EGFR Epidermal growth factor receptor
ENS Enteric nervous system
eNOS Endothelial nitric oxide synthase
ERK1/2 Extracellular signal-regulated kinase 1/2
F. prausnitzii Faecalibacterium prausnitzii
F/B Firmicutes/Bacteroidetes (ratio)
FASN Fatty acid synthase
FFAR2 Free fatty acid receptor 2
FFAR3 Free fatty acid receptor 3
FMC Fluoromethylcholine
FMO3 Flavin monooxygenase 3
FMT Fecal microbiota transplantation
FOXP3 Forkhead box P3
FXR Farnesoid X receptor
G6Pase Glucose-6-phosphatase
GABA Gamma-aminobutyric acid
GF Germ-free
GLP-1 Glucagon-like peptide 1
GPCR G-protein coupled receptor
GPR41 G-protein coupled receptor 41
H. pylori Helicobacter pylori
HDAC Histone deacetylase
HDACs Histone deacetylases
HDL High-density lipoprotein
HFD High-fat diet
HGM Human gut microbiome
HMG-CoA 3-hydroxy-3-methylglutaryl-coenzyme A
HSDH Hydroxysteroid dehydrogenase
I3C Indole-3-carbinol
IBD Inflammatory bowel disease
IBS Irritable bowel syndrome
ICAM-1 Intercellular adhesion molecule 1
IEC Intestinal epithelial cell
IECs Intestinal epithelial cells
IFIT1 Interferon-induced protein with tetratricopeptide repeats 1
IgA Immunoglobulin A
IgG Immunoglobulin G
IL-1 Interleukin-1
IL-1β Interleukin-1 beta
IL-6 Interleukin-6
IL-8 Interleukin-8
IMC Iodomethylcholine
isoalloLCA Isoallolithocholic acid
JNK c-Jun N-terminal kinase
LAL Limulus Amoebocyte Lysate
LBP Lipopolysaccharide-binding protein
LCA Lithocholic acid
LDL Low-density lipoprotein
LDLr Low-density lipoprotein receptor
LL-37 Cathelicidin antimicrobial peptide
LOX-1 Lectin-like oxidized low-density lipoprotein receptor-1
LPS Lipopolysaccharides
M1 Macrophage type 1
M2 Macrophage type 2
MAPK Mitogen-activated protein kinase
MCP-1 Monocyte chemoattractant protein 1
MCT1 Monocarboxylate transporter 1
MCT4 Monocarboxylate transporter 4
MD-2 Myeloid differentiation factor 2
MDA Malondialdehyde
MRSA Methicillin-resistant Staphylococcus aureus
mtROS Mitochondrial reactive oxygen species
MUC2 Mucin 2
MyD88 Myeloid differentiation primary response 88
NADPH Nicotinamide adenine dinucleotide phosphate
NEU1 Neuraminidase 1
NET Neutrophil extracellular trap
NF-κB Nuclear factor kappa B
NK Natural killer
NKT Natural killer T
NLRP3 NLR family pyrin domain containing 3
NO Nitric oxide
NOD1 Nucleotide-binding oligomerization domain 1
NOD1/2 Nucleotide-binding oligomerization domain 1/2
NOD2 Nucleotide-binding oligomerization domain 2
NPC1L1 Niemann-Pick C1-like 1
NR4A1 Nuclear receptor subfamily 4 group A member 1
NR4A2 Nuclear receptor subfamily 4 group A member 2
Nrf2 Nuclear factor erythroid 2-related factor 2
Olfr78 Olfactory receptor 78
OSTα/OSTβ Organic solute transporter alpha/beta
oxLDL Oxidized low-density lipoprotein
P. gingivalis Porphyromonas gingivalis
PAF Platelet-activating factor
PAMPs Pathogen-associated molecular patterns
PD-L1 Programmed death-ligand 1
PEPCK Phosphoenolpyruvate carboxykina
Biomarker A measurable biological parameter that reflects physiological or pathological processes, or response to a therapeutic intervention.
Dysbiosis An imbalance in gut microbiota composition, diversity, or function, associated with disease states.
Eubiosis A balanced microbial community structure compatible with health and homeostasis.
Fecal microbiota transplantation (FMT) Therapeutic transfer of stool from a healthy donor to a patient in order to restore microbiota balance.
Gut microbiota The community of microorganisms (bacteria, viruses, fungi, archaea) inhabiting the human gastrointestinal tract.
Microbiota-derived metabolites Small molecules produced by microbial metabolism (e.g., TMAO, SCFAs, bile acids) that can affect host physiology.
SCFAs (Short-chain fatty acids) Fermentation products of dietary fibers by gut microbiota, including acetate, propionate, and butyrate.
TMAO (Trimethylamine N-oxide) A gut microbiota-derived metabolite from dietary choline and carnitine, associated with cardiovascular risk.