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Regulation of LXR target gene expression by GW3965 in liver and intestine in apoE−/− mice. ApoE−/− mice (five animals per group) were treated for the indicated time with either vehicle or 10 mpk GW3965. Gene expression was measured by real-time quantitative PCR (Taqman) assays. Data are presented as mRNA expression relative to vehicle control. SREBP-1, sterol regulatory element binding protein-1.
