Table 1.
Plasma lipid levels in LDLR−/− mice maintained for 12 weeks on a high-fat diet in the presence or absence of GW3965
T = 0 Vehicle | 12 weeks
|
|||
---|---|---|---|---|
Vehicle | GW3965 (1 mpk) | GW3965 (10 mpk) | ||
Males | ||||
Total cholesterol, mg/dl | 319.8 ± 6.1 | 1233.9 ± 66.6 | 1014.3 ± 59.4* | 828.5 ± 109.6** |
HDL cholesterol, mg/dl | 126.5 ± 1.3 | 73.4 ± 2.9 | 69.4 ± 4.1 | 63.7 ± 8.1 |
Triglycerides, mg/dl | 96.9 ± 5.8 | 166.1 ± 22.6 | 172.0 ± 11.4 | 183.8 ± 28.8 |
Unesterified cholesterol, mg/dl | 81.9 ± 2.6 | 323.6 ± 16.9 | 272.9 ± 17.2 | 222.6 ± 29.7** |
Body weight, g | 22.8 ± 0.3 | 38.2 ± 0.7 | 37.3 ± 1.0 | 37.1 ± 0.5 |
Food intake, g/mouse | 269.8 ± 17.4 | 268.5 ± 24.9 | 275.8 ± 29.0 | |
Females | ||||
Total cholesterol, mg/dl | 265.5 ± 5.8 | 811.1 ± 41.7 | 862.1 ± 49.6 | 718.1 ± 28.1* |
HDL cholesterol, mg/dl | 96.0 ± 1.9 | 59.2 ± 3.7 | 68.1 ± 5.3 | 68.7 ± 6.2 |
Triglycerides, mg/dl | 90.7 ± 3.8 | 79.6 ± 6.7 | 78.4 ± 12.0 | 71.2 ± 9.3 |
Unesterified cholesterol, mg/dl | 73.7 ± 5.3 | 220.1 ± 11.4 | 222.0 ± 14.7 | 185.7 ± 7.5 |
Body weight, g | 17.0 ± 0.5 | 24.1 ± 1.0 | 23.6 ± 0.3 | 23.3 ± 0.4 |
Food intake, g/mouse | 288.5 ± 29.9 | 262.3 ± 17.7 | 284.5 ± 45.9 |
Data expressed as mean ± SEM.
, P < 0.05;
, P < 0.005. N = 9 per group.