Table 1.

Plasma lipid levels in LDLR^−/− mice maintained for 12 weeks on a high-fat diet in the presence or absence of GW3965

	T = 0 Vehicle	12 weeks
		Vehicle	GW3965 (1 mpk)	GW3965 (10 mpk)
Males
Total cholesterol, mg/dl	319.8  ± 6.1	1233.9  ± 66.6	1014.3  ± 59.4*	828.5  ± 109.6**
HDL cholesterol, mg/dl	126.5  ± 1.3	73.4  ± 2.9	69.4  ± 4.1	63.7  ± 8.1
Triglycerides, mg/dl	96.9  ± 5.8	166.1  ± 22.6	172.0  ± 11.4	183.8  ± 28.8
Unesterified cholesterol, mg/dl	81.9  ± 2.6	323.6  ± 16.9	272.9  ± 17.2	222.6  ± 29.7**
Body weight, g	22.8  ± 0.3	38.2  ± 0.7	37.3  ± 1.0	37.1  ± 0.5
Food intake, g/mouse		269.8  ± 17.4	268.5  ± 24.9	275.8  ± 29.0
Females
Total cholesterol, mg/dl	265.5  ± 5.8	811.1  ± 41.7	862.1  ± 49.6	718.1  ± 28.1*
HDL cholesterol, mg/dl	96.0  ± 1.9	59.2  ± 3.7	68.1  ± 5.3	68.7  ± 6.2
Triglycerides, mg/dl	90.7  ± 3.8	79.6  ± 6.7	78.4  ± 12.0	71.2  ± 9.3
Unesterified cholesterol, mg/dl	73.7  ± 5.3	220.1  ± 11.4	222.0  ± 14.7	185.7  ± 7.5
Body weight, g	17.0  ± 0.5	24.1  ± 1.0	23.6  ± 0.3	23.3  ± 0.4
Food intake, g/mouse		288.5  ± 29.9	262.3  ± 17.7	284.5  ± 45.9

Data expressed as mean ± SEM. 

^*, P < 0.05; 

^**, P < 0.005. N = 9 per group.