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. 2002 May 14;99(11):7604–7609. doi: 10.1073/pnas.112059299

Table 1.

Plasma lipid levels in LDLR−/− mice maintained for 12 weeks on a high-fat diet in the presence or absence of GW3965

T = 0 Vehicle 12 weeks
Vehicle GW3965 (1 mpk) GW3965 (10 mpk)
Males
 Total cholesterol, mg/dl 319.8  ± 6.1 1233.9  ± 66.6 1014.3  ± 59.4* 828.5  ± 109.6**
 HDL cholesterol, mg/dl 126.5  ± 1.3 73.4  ± 2.9 69.4  ± 4.1 63.7  ± 8.1
 Triglycerides, mg/dl 96.9  ± 5.8 166.1  ± 22.6 172.0  ± 11.4 183.8  ± 28.8
 Unesterified cholesterol, mg/dl 81.9  ± 2.6 323.6  ± 16.9 272.9  ± 17.2 222.6  ± 29.7**
 Body weight, g 22.8  ± 0.3 38.2  ± 0.7 37.3  ± 1.0 37.1  ± 0.5
 Food intake, g/mouse 269.8  ± 17.4 268.5  ± 24.9 275.8  ± 29.0
Females
 Total cholesterol, mg/dl 265.5  ± 5.8 811.1  ± 41.7 862.1  ± 49.6 718.1  ± 28.1*
 HDL cholesterol, mg/dl 96.0  ± 1.9 59.2  ± 3.7 68.1  ± 5.3 68.7  ± 6.2
 Triglycerides, mg/dl 90.7  ± 3.8 79.6  ± 6.7 78.4  ± 12.0 71.2  ± 9.3
 Unesterified cholesterol, mg/dl 73.7  ± 5.3 220.1  ± 11.4 222.0  ± 14.7 185.7  ± 7.5
 Body weight, g 17.0  ± 0.5 24.1  ± 1.0 23.6  ± 0.3 23.3  ± 0.4
 Food intake, g/mouse 288.5  ± 29.9 262.3  ± 17.7 284.5  ± 45.9

Data expressed as mean ± SEM. 

*

, P < 0.05; 

**

, P < 0.005. N = 9 per group.