Figure 4.

Effect of sulforaphane on benzo[a]pyrene-induced neoplasia of the forestomach in female wild-type and nrf2-deficient mice. Female mice (9–12 wk old) were fed sulforaphane at an estimated intake of 7.5 μmol per animal per day, for a period extending from 7 days before, to 2 days after the last dose of carcinogen. Dosing with benzo[a]pyrene (120 mg/kg in 0.2 ml corn oil by gavage), was at four consecutive weekly intervals, and animals were killed 20 wk after the first benzo[a]pyrene treatment. Gastric tumors are reported as follows: (number of gastric tumors in the entire group)/(number of mice at risk at termination of experiment). Two animals in the nrf2-deficient control group had tumors too numerous to count. Open bar, vehicle-treated; filled bar, sulforaphane-treated. Error bars are ± SEM.