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. 2025 Aug 24;30(17):3477. doi: 10.3390/molecules30173477
ACN Acetonitrile
ANOVA Analysis of Variance
A→B Apical to Basolateral
B→A Basolateral to Apical
BCS Biopharmaceutics Classification System
CAPES Coordination for the Improvement of Higher Education Personnel
CV Coefficient of Variation
DMEM Dulbecco’s Modified Eagle Medium
DMSO Dimethyl Sulfoxide
EMA European Medicines Agency
ESI Electrospray Ionization
ER Efflux Ratio
FAPESP São Paulo Research Foundation
FBS Fetal Bovine Serum
FDA Food and Drug Administration
HBSS Hank’s Balanced Salt Solution
HEPES N-(2-hydroxyethyl)piperazine-N′-(2-ethanesulfonic acid)
INT Iodonitrotetrazolium
IS Internal Standard
LDH Lactate Dehydrogenase
LOD Limit of Detection
LLOQ Lower Limit of Quantification
MF Matrix Factor
MES 2-(N-morpholino)ethanesulfonic acid
MRM Multiple Reaction Monitoring
NEAA Non-Essential Amino Acids
N/A Not Applicable
PBS Phosphate-Buffered Saline
Papp Apparent Permeability Coefficient
P-gp P-glycoprotein
QC Quality Control
RE Relative Error
SPE Solid-Phase Extraction
TEER Transepithelial Electrical Resistance
ULOQ Upper Limit of Quantification
UPLC-MS/MS Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry
WHO World Health Organization