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Bioinformatics analysis of the genomic sequences of the RARα and TopoII A genes. Exons are shown as boxes and black arrows indicate the breakpoints of the RARα gene in patients with PML-RARα L-type isoform. Note a typical RARE motif of DR5 (red arrow) is located upstream of the α2Ex1. The sizes of introns 1–8 of the RARα gene (not considering the α1Ex1) are 12,408, 16,919, 1,319, 1,984, 260, 1,794, 756, and 587 bp, respectively.
