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. 2002 May 21;99(11):7640–7645. doi: 10.1073/pnas.112194799

Figure 2.

Figure 2

(A) Spacer sequences in PML-RARα V-type isoform from the intron 2 of the RARα gene. G-cases are from the study by Slack et al. (24); P-cases are from the study by Pandolfi et al. (16), and F-cases are from this work. Some spacers were used in more than one case, as underlined. Note the consensus splicing sites (bold) at the 3′ end (with uppercase letters) and downstream of the “cryptic” coding region (with lowercase letters). Black arrows indicate the deduced genomic breakpoints in the RARα gene. (B) Relationship between spacer insertion site in mRNA and genomic breakpoint (showed by black arrow) in RARα gene in the F1 case. (C) Nucleic acid and protein sequences of the fusion region of F1 PML-RARα. The spacer sequence is indicated in blue, containing a possible protein–protein interaction motif (5 amino acids in the box).