Table 6.

Univariate and multivariate logistic analysis of predictive factors for achieving pCR

Variables	Univariate analysis			Multivariate analysis
	OR	95%CI	P	OR	95%CI	P
Objective response rate	0.696	0.531-0.912	0.999
Age (≥65 years)	0.333	0.034-3.261	0.345	3.156	0.280-35.543	0.352
Sex (Male)	0.133	0.020-0.876	0.849
Smoking status (Current or former smoker)	0.286	0.046-1.780	0.180
ECOG Physical Score (0)	2.222	0.402-12.285	0.360
Preoperative nodal stage(N2)	1.821	0.321-10.342	0.499
Downstaging of nodal status in patients with N2 or N1 at baseline (N2 to N2 or N1 to N1)	0.563	0.365-0.867	0.998
Stage at presentation (IIB and IIIA)	1.465	0.530-4.049	0.462
PD-L1 expression (≤1%)	0.119	0.012-1.149	0.066
TMB (Tumor mutational burden) (≤5.7)	0.100	0.010-0.970	0.047	10.210	1.025-101.726	0.048