Table 8.

Treatment-related adverse events

	Grade 1–2	Grade 3-4
Fatigue	13(40.6%)
Nausea or Vomiting	12(37.5%)
Rash	11(34.4%)	1(3.1%)
Neutropenia	9(28.1%)	1(3.1%)
Constipation	7(21.9%)
Diarrhoea*	6(18.8%)
Arthralgia or myalgia*	5(15.6%)
Hepatic dysfunction*	4(12.5%)
Anaemia	4(12.5%)
Hypothyroidism*	4(12.5%)
Thrombocytopenia	3(9.4%)
Anorexia	3(9.4%)

Data are n (%). Shown are the treatment-related adverse events of any grade that occurred in more than 10% of patients, or any treatment-related adverse events of grade 3 and above. No grade 5 treatment-related adverse events were reported.

^*Possible immune-mediated adverse events.