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. 2002 May 21;99(11):7646–7651. doi: 10.1073/pnas.112039899

Figure 6.

Figure 6

Sic-specific synthetic peptides inhibit the adherence of M1 GAS to human epithelial cells and Sic binding to ezrin. (A) Schematic of Sic1.01 showing the position of 10 peptides projected to be surface-exposed regions. Ss, signal sequence; SRR, short repeat region; R1, R2, and R2, tandem repeats R1, R2, and R3, respectively. (B) MGAS5005sic was incubated with A549 cells in the presence of Sic1.01 or a 5-fold molar excess (final concentration 1.6 μM) of each of the 10 synthetic peptides. Results are expressed as percent GAS attachment relative to bacterial binding in the absence of peptide. (C) Peptides #2 and #7 inhibit Sic binding to glutathione-agarose beads coated with the GST fusion protein Ez531–586. Results are expressed as percent Sic binding relative to Sic binding in the absence of peptide.