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Reduction of the plaque load in ZnT3−/− mice. (A) Age-dependent increases in the number of amyloid plaques (mean ± SEM, n = 3–5 each) in hAPP+ female mice with indicated ZnT3 genotypes. Asterisks denote difference from ZnT3+/+ (P < 0.01). (B) Percent area occupied by congophilic amyloid plaques in coronal brain sections of 15- or 18-month-old female hAPP+ mice with indicated ZnT3 genotypes. Asterisks represent significant difference (P < 0.05).
