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Reduced plaque sizes in hAPP+:ZnT3−/− mice. Photomicrographs of frontal cortex (A and D), parietal cortex (B and E), and hippocampi (C and F) of 18 month-old female ZnT3+/+ (A–C) and ZnT3−/− (D–F) hAPP+ mice stained with Congo red. Note that plaques in ZnT3−/− brains are much smaller than those in ZnT3+/+ (also see Table 1). (Bar = 100 μm.)
