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. 2002 Apr 30;99(11):7705–7710. doi: 10.1073/pnas.092034699

Figure 6.

Figure 6

The absence of synaptic zinc alters levels of soluble and insoluble Aβ. (A) Bars denote concentrations of insoluble and soluble Aβ40 and Aβ42 (μg/g of brain tissue; mean + SEM, n = 3 each) in 12-month-old male (empty bars) and female (filled bars) hAPP+ mice with indicated ZnT3 genotypes. (B) Concentrations of insoluble and soluble Aβ40 and Aβ42 (μg/g of brain tissue) in 18-month-old male (empty bars) and female (filled bars) hAPP+ mice with indicated ZnT3 genotypes (n = 2). (C) Correlations between levels of insoluble Aβ42/Aβ40 and total zinc. Regression analysis showed positive correlations in both cases (P < 0.01).