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Proposed molecular cascade of visual cortical plasticity. Inhibitory-excitatory balance detects perturbed sensory input (18)(a). Neuromodulators (b) regulate coupling (29) to protein kinase A (30)(c); phosphorylation of MAP kinase (35) and CREB (24) (d) reciprocally induces and is stimulated by BDNF (34)(e), which is known to release tPA from cortical neurons (33).
