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Mutation within CRE abolishes the response of the promoter to cell-signaling stimulation. JEG-3 cells were transfected with a luciferase construct with either wild-type or CRE-mutated mPer1 promoter (A), or with isolated wild-type or mutated CRE motifs of mPer1 and mPer2 promoters (B). Stimulation and luciferase assays were done as in Fig. 3.
