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. 2025 Sep 1;16:1618240. doi: 10.3389/fneur.2025.1618240

Table 2.

Channels with significant differences of mean Oxy-Hb changes between CSVD with and without sleep disturbance.

Channel Location Mean Oxy-Hb changes in 60s task period (mmol/L*mm) t/Z Unadjusted, p-value p-value (FDR corrected)
CSVD + S CSVD − S
6 R-mPFC −0.009 (−0.025, 0.010) 0.017 (0, 0.045) −4.244 <0.001 <0.001
8 R-mPFC −0.010 (−0.023, 0.015) 0.011 (−0.012, 0.038) −3.226 0.001 0.002
10 L-mPFC 0.002 (−0.020, 0.032) 0.033 (0.002, 0.059) −3.317 <0.001 0.002
28 R-mPFC −0.008 (−0.026, 0.009) 0.009 (−0.009, 0.032) −3.756 <0.001 <0.001
42 R-DLPFC −0.005 ± 0.025 0.009 ± 0.026 −3.083 0.003 0.003

CSVD, cerebral small vessel disease; CSVD + S, CSVD with sleep disturbance; CSVD − S, CSVD without sleep disturbance; Oxy-Hb, oxyhemoglobin; R, right; L, left; mPFC, medial prefrontal cortex; DLPFC, dorsolateral prefrontal cortex; FDR, false discovery rate.