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. 2002 May 21;99(11):7746–7750. doi: 10.1073/pnas.122205699

Figure 2.

Figure 2

Brief application of the mGluR agonist DHPG (5 min; 100 μM) induces greater LTD of synaptic responses in hippocampus of Fmr1-KO mice as compared with WT littermate controls. (A1) Plotted are average (±SEM) FP slope values over the time course of the experiment. In Fmr1-KO animals, the response 60 min after treatment was depressed to 77 ± 3% of preDHPG baseline (n = 21 slices from 9 mice; open circles); in interleaved WT controls, the response was depressed to 88 ± 4% of baseline (n = 15 slices from 8 mice; filled circles; different at P = 0.02; t test). (A2) Representative FPs (2 min average) taken at the times indicated by the numbers on the graph. (Bar = 1 mV; 5 msec.) (B) Cumulative probability distributions of FP slope values (% of baseline), measured 1 h after DHPG in individual slices from both KO and WT groups. The distribution in KO mice is significantly different from that in WT mice as determined by Kolmolgarov–Smirnov test (P < 0.05).