3. Improvement in PK Parameters via Linker and CRBN Ligand Modification.


*Racemic at 3-hydroxypiperidine. **Units of nM. @Units of mL/min/kg. $Units of 10–6 cm/s. #IV (2 mg/kg)/PO (10 mg/kg), Cl in units of mL/min/kg, Vss in units of L/kg, T 1/2 in units of h.