FIGURE 2.

Example of high interobserver variation with the New method (white line with red outline) but not the Old method (solid blue line). The depth of invasion (DOI) of a vulvar squamous cell carcinoma is measured by 2 different pathologists (A and B) using the 2 methods. The pathologists agree that DOI is >1 mm using the Old method. They produce measurements spanning 1 mm using the New method, with Pathologist A measuring 0.18 mm from a separated invasive nest to the base of the complex mass, whereas Pathologist B regards the entire mass as invasive yielding DOI of 1.64 mm.