Table 4.
Epigenome-wide suggestive (p < 1E–5) DNA methylation changes (Mean Diff.) from T0 (baseline) to T1 (post-treatment) and to T2 (6-month follow-up), respectively, in a responders to cognitive-behavioral therapy (CBT) in patients with anxiety disorders (T0–T1: N = 133; T0–T2: N = 141).
| T0–T1 | ||||||
|---|---|---|---|---|---|---|
| CpG | T-Value | P-Value | Mean Diff. T0–T1 | Nearest Gene Annotation | Previous Functional Evidence | Reference |
| – | – | – | – | – | – | – |
| T0–T2 | ||||||
| CpG | T-Value | P-Value | Mean Diff. T0-T2 | Nearest Gene Annotation | Previous Functional Evidence | Reference |
| cg04624514 | −4.739 | 5.212E–06 | −0.00085 (−0.1%) | TMCC1 |
• CircTmcc1 contributed to the secretion of proinflammatory mediators and glutamate metabolism in astrocytes and subsequently modulated an improvement in spatial memory by mediating neuronal synaptic plasticity • Associated with anxiety disorders in granulocytes in a cross-anxiety disorder EWAS |
[25, 94] |
| cg00666772 | 4.659 | 7.317E–06 | −0.00018 (−0.02%) | OCA2 | • Associated with anxiety disorders in monocytes in a cross-anxiety disorder EWAS | [25] |
| cg21601852 | 4.612 | 8.917E–06 | −0.0011 (0.12%) | ADIPOR2 |
• Adiponectin-deficient mice exhibited normal contextual fear conditioning but displayed slower extinction learning • Infusions of adiponectin into the dentate gyrus of the hippocampus in fear-conditioned mice facilitated extinction of contextual fear • Targeting adiponectin/AdipoR2 have been suggested to strengthen extinction-based exposure therapies • Adiponectin-KO mice displayed increased anxiety at 9 and 18 months • Associated with anxiety disorders in granulocytes in a cross-anxiety disorder EWAS |
[25, 95–97] |
| cg21474639 | 4.597 | 9.472E–06 | −0.00041 (−0.05%) | EIF3B | – | – |
Mean Diff.: negative values indicate a decrease in methylation from T0–T2.
aresponders to CBT were defined according to a T0 to T1/T2 change of ≥ 50% in Hamilton Anxiety Rating Scale (HAM-A) scores (see “Treatment”).