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. 2025 Sep 2;16:1530508. doi: 10.3389/fimmu.2025.1530508

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Copyright © 2025 Ou, Li, Zhi, Huang and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Flowchart depicting the analysis process for NETs-related genes starting from dataset GSE87466. It involves steps like identifying differentially expressed genes, performing correlation analysis, using WGCNA for module identification, and validating hub genes with datasets GSE206285, GSE92415, GSE12251, and GSE16879. The process includes GSVA Enrichment, immune infiltration, and various analyses leading to an anti-TNF prognostic model and nomogram development. — Study flowchart.