Figure 1.

Abnormal phenotypes in skin and hair of TRAF6^−/− mice. (A and B) Abnormal external appearances common to TRAF6^−/− mice and mutant mice with HED. (C) Appearance of TRAF6^−/− mice (lower) and heterozygous (upper) mice at day 1. TRAF6^−/− mice have more translucent skin than their littermates and appear similar to albino neonates. (D and E) Flat-mount sections of back skin of TRAF6^−/− mice and their heterozygous littermates, respectively, at day 1. Note that small unpigmented hair follicles (clear small spots) are present even in the back skin of TRAF6^−/− mice.