Lack of guard hair follicles in juvenile TRAF6−/− mice. (A and B) Sections of back skin of mice at day 11. Guard hair follicles, which are larger than other follicles, are visible in back skin of their heterozygous littermates (A, arrow). (C and D) Sections of tail skin at day 8. (E and F) Fine structure of pelage hairs of dl mice and that of TRAF6−/− mice. TRAF6−/− mice (B, D, and F), heterozygous littermates (A and C), and dl mice (E).