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. 2002 Jun 19;99(13):8892–8897. doi: 10.1073/pnas.092259799

Figure 1.

Figure 1

Anti-Fas Ab-induced generation of intracellular NO. (a) Anti-Fas Ab (10–100 ng/ml) induced a concentration-dependent shift in fluorescence of DAF-2/DA. Measurements made 40 min after addition of the Ab. (b) Time dependence of the production of NO in response to anti-Fas Ab (10 ng/ml). (c) l-NAME (500 μM) alone had no effect on the DAF-2/DA fluorescent signal but caused a significant shift in the response to anti-Fas Ab (10 ng/ml) toward the baseline value. Measurements made 1.5 h after addition of Ab. Results shown are representative or the mean ± SEM of five experiments.