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. 2002 Jun 17;99(13):8898–8902. doi: 10.1073/pnas.132067399

Figure 2.

Figure 2

Time course of the LH level in serum of castrated rats after administration of the test substances. (a) s.c. administration of the unmodified Spiegelmer NOX 1255 (●, blue). (b) i.v. administration of PEGylated Spiegelmer NOX 1257 (●, blue). The control groups received Cetrorelix (▴, green) and vehicle (■, red). A group of intact animals receiving vehicle (⋄, black) provided the baseline level of LH. The blood samples were analyzed by RIA. Each data point represents the average value of all animals per group. d1 represents the LH concentration before castration. The suppression observed in the experiment shown in a was not statistically significant; however, the suppression found in the experiment shown in b showed a clear statistical significance. One animal that received NOX 1257 showed a delayed response, causing the slight increase of the curve at time point 3 h.