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Time course of Spiegelmer-specific antibody titer in the serum of rabbits after repeated administration of NOX 1255 (a) and NOX 1257 (b). The groups received either Spiegelmer (□), Spiegelmer in combination with adjuvant (□), and Spiegelmer conjugated to cBSA in combination with adjuvant (■) compared with cBSA-specific antibody titer in the serum of animals from the last group ( ). Blood samples for the analysis with ELISA were drawn before each boost.
