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. 2025 Sep 12;21:2067–2082. doi: 10.2147/NDT.S533262

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© 2025 Hua et al.

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Comparison of MRI changes before and after treatment in two cases. (A) T2 fluid attenuated inversion recovery images of subject no.20 before treatment, showing high signal intensity near the lateral ventricle and dysplasia indicative of myelin deficiency; (B) Improvements after 90 days of treatment (red arrow). (C) A slightly wider frontotemporal space in the apparent diffusion coefficient map of subject no.36 before treatment; (D) MRI changes after 90-day of treatment, showing improved white matter in the right temporal lobe (red arrow).