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Effect of theophylline on HDAC activity. BAL macrophages were incubated for 12 h with LPS after treatment with theophylline for 10 min or dexamethasone for 30 min. HDAC activity (a) and IL-8 secretion (b) were measured in normal nonsmoking subjects as described in Materials and Methods. Results are expressed as mean ± SEM (n = 5; *, P < 0.05; **, P < 0.01 vs. LPS control; ***, P < 0.05 vs. unstimulated cells.
