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. 2025 Sep 16;27:e77014. doi: 10.2196/77014

Table 4. Comparison of treatment effects between the groups at posttreatment (intent-to-treat analysis). Differences from the baseline are expressed as mean differences and 95% confidence intervals.

Measurement Unadjusted mean (SD) Adjusted difference (95% CI) Between-group effect
Size d (95% CI)
Within-group effect size d
(95% CI)
Usual care Fitness walking Tai Chi Fitness walking versus usual care P value Tai Chi versus
Usual care
P value Fitness walking versus usual care Tai Chi versus usual care Usual care Fitness walking Tai Chi
MoCAa score 22.96 (3.01) 22.94 (3.41) 23.83 (4.06) –0.02 (–0.11 to 0.06) .421 0.87 (0.25 to 2.31) .002 0.79 (0.44 to 1.26) 0.98 (0.51 to 1.74) 0.15 (0.08 to 0.79) 0.46 (0.28 to 0.51) 0.71 (0.39 to 0.99)
MQb 90.17 (11.26) 91.93 (10.59) 99.23 (17.08) 1.76 (0.84 to 2.04) .582 9.06 (6.51 to 11.38) .003 0.36 (0.24 to 0.65) 0.73 (0.58 to 0.95) 0.07 (0.02 to 0.13) 0.21 (0.15 to 0.42) 0.66 (0.32 to 0.85)
Digit Symbol Substitution Testc score 29.74 (8.05) 33.92 (4.48) 37.84 (5.59) 4.18 (2.83 to 6.53) .011 8.10 (4.62 to 10.88) .025 0.67 (0.33 to 0.89) 0.83 (0.20 to 0.95) 0.11 (0.09 to 0.22) 0.41 (0.18 to 0.72) 0.52 (0.31 to 0.67)
TMT-Bd finding 225.19
(8.93)
220.81
(12.73)
207.33
(12.25)
−4.55 (−7.09 to −3.11) .611 −17.94 (−25.89 to −13.51) .022 0.21 (0.13 to 0.56) 0.77 (0.40 to 0.81) 0.21 (0.18 to 0.44) 0.20 (0.07 to 0.47) 0.77 (0.45 to 0.83)
Boston Naming Teste score 22.97
(4.02)
25.94
(4.11)
26.61
(4.18)
3.03 (2.01 to 4.69) .026 4.34 (2.11 to 6.87) .001 0.11 (0.05 to 0.49) 0.69 (0.42 to 0.89) 0.37 (0.24 to 0.59) 0.38 (0.12 to 0.52) 0.47 (0.33 to 0.68)
Rey-Osterrieth Complex Figure Testf score 31.78
(6.63)
34.98
(6.77)
34.64
(5.01)
3.02 (2.62 to 4.01) .422 3.02 (2.62 to 4.01) .417 0.25 (0.17 to 0.40) 0.33 (0.12 to 0.45) 0.10 (0.04 to 0.25) 0.39 (0.22 to 0.57) 0.41 (0.30 to 0.71)
Rey-Osterrieth Complex Figure Test delayed recall score 13.37
(7.01)
15.48
(7.11)
18.39
(7.83)
2.87
(1.55 to 4.24)
.477 5.01
(2.78 to 7.16)
.021 0.16
(0.07 to 0.33)
0.73
(0.56 to 0.81)
0.29 (0.10 to 0.47) 0.39 (0.11 to 0.68) 0.78 (0.66 to 0.94)
a

MoCA: Montreal Cognitive Assessment.

b

MQ: Wechsler Memory Quotient.

c

DSST: Digit Symbol Substitution Test score.

d

TMT-B: Trail Making Test part B.

e

BNT: Boston Naming Test.

f

ROCF: Ray Complex Figure Test.