Table 2.
Pathogenicity of H5N1 influenza viruses for animals following experimental infection
| Virus | Genotype | Avian infection: No. dead/no. inoculated (days to death)
|
Mouse infection
|
|||
|---|---|---|---|---|---|---|
| Chicken* | Quail* | No. dead/no. inoculated† | Virus in lung (mean log10 EID50)‡ | Virus in brain (mean log10 EID50)‡ | ||
| Gs/HK/437.6/99 | Gs/Gd/96-like | 8/8 (2–6) | 7/8 (4–7) | 0/10 | 4.2 | No |
| Gs/HK/437.10/99 | Gs/Gd/96-like | 7/8 (3–9) | 6/8 (4–7) | 4/8 | 2.3 | No |
| Ck/HK/YU822.1/01 | A | 8/8 (1) | 4/4 (1–2) | 11/15 | 2.5 | Yes (3.5) |
| Ck/KH/YU562/01 | B | 8/8 (1) | 4/4 (5–6) | 13/20 | 2.6 | No |
| Ph/HK/FY155/01 | C | 8/8 (1–2) | 4/4 (3–4) | 17/18 | 4.6 | Yes (4.3) |
| Ck/HK/FY150/01 | D | 8/8 (1–3) | 4/4 (4–5) | 8/13 | 3.8 | Yes (2.8) |
| Ck/HK/873.3/01 | E | 8/8 (1) | 4/4 (2–3) | 6/18 | 2.8 | Yes (3.5) |
*
The dose used was 105–106 egg infection dose (EID50). Routes of inoculation used were as follows: chicken, i.v.; quail, combination of oral, intranasal, and orbital routes; Balb/c mice, intranasal.
†
Mice observed for 10 days.
‡
Mean of results from three mice.