Table 3.
Dosage regimen recommendations to attain a therapeutic range of phenobarbital based on the age and weight of the individual dogs.
| Weight (kg) | Age (years) | |||
|---|---|---|---|---|
| ≤1 | 1–7 | ≥7 | ||
| Less than 10 | Loading dose. | 25 mg/kg single dose. | 25 mg/kg single dose. | 20 mg/kg/24 h from 0 to 48 h. |
| Progression dose. | 5 mg/kg/12 h from 24 h for 5 days | 5 mg/kg/12 h from 24 h for 5 days | 3 mg/kg/12 h for 5 days | |
| Maintenance dose. | 8 mg/kg/12 h | 6 mg/kg/12 h | 5 mg/kg/12 h | |
| 10 to 25 | Loading dose. | 25 mg/kg single dose | 25 mg/kg single dose. | 20 mg/kg single dose |
| Progression dose. | 4 mg/kg/12 h from 24 h for 5 days | 3 mg/kg/12 h from 24 h for 5 days | – | |
| Maintenance dose. | 6 mg/kg/12 h | 5 mg/kg/12 h | 4 mg/kg/12 h | |
| More than 25 | Loading dose. | 25 mg/kg single dose. | 20 mg/kg single dose | 20 mg/kg single dose |
| Progression dose. | 3 mg/kg/12 h from 24 h for 5 days | – | – | |
| Maintenance dose. | 5 mg/kg/12 h | 3 mg/kg/12 h | 3 mg/kg/12 h | |