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. 2025 Sep 3;12:1644003. doi: 10.3389/fvets.2025.1644003

Table 3.

Dosage regimen recommendations to attain a therapeutic range of phenobarbital based on the age and weight of the individual dogs.

Weight (kg) Age (years)
≤1 1–7 ≥7
Less than 10 Loading dose. 25 mg/kg single dose. 25 mg/kg single dose. 20 mg/kg/24 h from 0 to 48 h.
Progression dose. 5 mg/kg/12 h from 24 h for 5 days 5 mg/kg/12 h from 24 h for 5 days 3 mg/kg/12 h for 5 days
Maintenance dose. 8 mg/kg/12 h 6 mg/kg/12 h 5 mg/kg/12 h
10 to 25 Loading dose. 25 mg/kg single dose 25 mg/kg single dose. 20 mg/kg single dose
Progression dose. 4 mg/kg/12 h from 24 h for 5 days 3 mg/kg/12 h from 24 h for 5 days
Maintenance dose. 6 mg/kg/12 h 5 mg/kg/12 h 4 mg/kg/12 h
More than 25 Loading dose. 25 mg/kg single dose. 20 mg/kg single dose 20 mg/kg single dose
Progression dose. 3 mg/kg/12 h from 24 h for 5 days
Maintenance dose. 5 mg/kg/12 h 3 mg/kg/12 h 3 mg/kg/12 h