Table 2.
Differential mortality in stage 3 CKM: competing risks of CKD-dominant vs. CVD-dominant phenotypes.
| Onset age (years) | Control subjects | Case subjects | Hazard ratio (95% CI) | P value | ||
|---|---|---|---|---|---|---|
| Event/Total | Rate | Event/Total | Rate | |||
| New-onset CKM syndrome Stage 3 with very high-risk CKD (P for interaction = 0.009) | ||||||
| <45 | 4/1070 | 0.45 | 7/1002 | 0.83 | 2.39 (0.59 - 9.71) | 0.224 |
| 45-54 | 37/951 | 4.08 | 46/483 | 10.63 | 3.25 (2.06 - 5.13) | <0.001 |
| 55-64 | 263/3421 | 8.93 | 98/511 | 22.32 | 2.92 (2.28 - 3.74) | <0.001 |
| ≥65 | 1442/5924 | 30.26 | 106/288 | 46.29 | 1.96 (1.60 - 2.41) | <0.001 |
| New-onset CKM syndrome Stage 3 with high predicted CVD risk (P for interaction < 0.001) | ||||||
| <45 | 4/1070 | 0.45 | 7/68 | 11.77 | 24.06 (3.94 - 146.92) | <0.001 |
| 45-54 | 37/951 | 4.08 | 57/476 | 12.70 | 2.82 (1.80 - 4.41) | <0.001 |
| 55-64 | 263/3421 | 8.93 | 370/2954 | 14.98 | 1.66 (1.41 - 1.97) | <0.001 |
| ≥65 | 1442/5924 | 30.26 | 1507/5723 | 31.99 | 1.01 (0.93 - 1.09) | 0.836 |
Data presented as hazard ratio (95% confidence interval), with event rates per 100 person-years.
P values for phenotype-age interaction terms: very high-risk CKD cohort = 0.009, high predicted CVD risk cohort < 0.001. Control subjects: Age-matched individuals without cardio-kidney-metabolic dysfunction. Case subjects: New-onset Stage 3 CKM patients stratified by predominant phenotype.