Table 2.
Linear mixed-effects models for cognitive measures.
| Predictors | MMSE | CDR-SB | ||
|---|---|---|---|---|
| Estimates [95% CIs] | p values | Estimates [95% CIs] | p values | |
| Age × Time | −0.005 [−0.014, 0.004] | 0.263 | 0.007 [0.002, 0.013] | 0.011 |
| Female sex × Time | −0.254 [−0.377, −0.131] | <0.001 | 0.218 [0.144, 0.292] | <0.001 |
| Education × Time | −0.017 [−0.034, 0.001] | 0.069 | 0.017 [0.006, 0.028] | 0.002 |
| APOE4 carriers × Time | −0.639 [−0.754, −0.523] | <0.001 | 0.555 [0.485, 0.625] | <0.001 |
| Plasma VWF × Time | 0.204 [0.030, 0.378] | 0.021 | −0.268 [−0.374, −0.163] | <0.001 |
The models included the coefficients of the main effects of the predictors, but these coefficients were not shown in the table for the sake of brevity.
MMSE, Mini-Mental State Examination; CDR-SB, Clinical Dementia Rating Sum of Boxes; CIs, Confidence intervals; APOE4, Apolipoprotein E; VWF, von Willebrand Factor.