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. 2025 Sep 3;15:1600980. doi: 10.3389/fonc.2025.1600980

Figure 7.

Graph A illustrates CNR values before and after MVD across cases 24, 37, 41, 55, and 56, showing an increase post-MVD. Graph B compares CNR values using MVD and FLOW800 methods for cases 37 and 56, with both cases showing higher values using FLOW800.

Paired contrast-to-noise ratio (CNR) comparisons in five patients undergoing skull base tumor resection. (A) CNR values before and after intraoperative microvascular Doppler (MVD) application in Cases 24, 41, 55, 56, and 37, demonstrating consistent improvement following Doppler-based vessel identification. (B) CNR values from MVD and FLOW800 images in Cases 37 and 56, showing higher vessel-to-background contrast with fluorescence-based perfusion imaging. Each line connects the same patient. CNRs were calculated independently from grayscale images acquired using each modality. No image merging or overlay was performed.