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. 2025 Sep 3;12:1650124. doi: 10.3389/fmed.2025.1650124

Figure 6.

Bar chart comparing the logarithmic hazard ratios (log HR) for various biomarkers between alcoholic and non-alcoholic groups. Spleen shows the highest log HR of 2.92 for the alcoholic group. Other notable values include PVD at 2, INR at 1.93, and IEVs at 1.63. The color gradient from light to dark red indicates increasing log HR values.

Heatmap of log-transformed hazard ratios (log[HR]) for prognostic biomarkers predicting hepatic decompensation in patients with compensated cirrhosis, stratified by etiology (alcoholic vs. non-alcoholic). Each cell represents the log-transformed hazard ratio derived from a meta-analysis of the association between a specific biomarker and liver failure. Warmer colors (red) indicate stronger positive associations (higher HR), while cooler colors (blue) reflect weaker associations. The heatmap highlights that structural biomarkers such as portal vein diameter (PVD) and spleen size, along with inflammatory markers, have the highest predictive value, particularly in cases of non-alcoholic cirrhosis.