Table 1. In vitro cytotoxicity of toxyloxanthone C and macluraxanthone derivativesa.
| Compound | Cytotoxicity (IC50, μM) | |||
|---|---|---|---|---|
| HelaS3 | A549 | HepG2 | Vero | |
| 1a | 22.61 ± 2.02 | 12.20 ± 1.08 | 21.10 ± 1.18 | >100 |
| 1b | 20.46 ± 4.92 | 5.77 ± 2.14 | 17.15 ± 4.50 | 5.59 ± 0.36 |
| 1c | 65.33 ± 3.92 | >100 | >100 | >100 |
| 1d | >100 | >100 | >100 | >100 |
| 1e | 50.39 ± 8.45 | >100 | >100 | >100 |
| 1f | 17.43 ± 1.75 | 7.52 ± 0.36 | 19.42 ± 1.52 | 9.52 ± 1.02 |
| 2a | 25.55 ± 4.77 | 15.66 ± 1.17 | 24.54 ± 2.98 | 10.10 ± 1.67 |
| 2b | 55.31 ± 2.18 | 41.84 ± 1.91 | >100 | 35.95 ± 2.32 |
| 2c | 84.26 ± 7.86 | 48.83 ± 4.73 | >100 | >100 |
| 2d | >100 | >100 | >100 | >100 |
| 2e | >100 | 90.46 ± 6.23 | >100 | >100 |
| 2f | >100 | >100 | >100 | >100 |
| 2g | >100 | >100 | >100 | >100 |
| 1 | 13.55 ± 1.11 | 21.78 ± 4.89 | 20.81 ± 2.57 | 8.52 ± 0.64 |
| 2 | 1.59 ± 0.12 | 6.46 ± 0.98 | 5.26 ± 0.41 | 4.29 ± 0.60 |
| Doxorubicin | 0.29 ± 0.02 | 0.48 ± 0.036 | 0.37 ± 0.02 | 1.95 ± 0.13 |
a
HelaS3 = human cervical carcinoma, A549 = human lung carcinoma, HepG2 = human hepatocellular carcinoma, Vero = African green monkey kidney.