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. 2002 Jun 17;99(13):9037–9042. doi: 10.1073/pnas.122623799

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Copyright © 2002, The National Academy of Sciences

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Complex functional redundancy of Munc13 isoforms. (A) Examples of EPSCs recorded from cells of the indicated genotypes. (B) Mean EPSC amplitudes measured in cells of the indicated genotypes. (C) Mean readily releasable vesicle pool sizes in cells of the indicated genotypes as estimated by the charge integral measured after release induced by application of 500 mOsm hypertonic sucrose solution for 4 s. (D) mEPSC activity recorded in cells of the indicated genotypes. Holding potential −70 mV. (E) Examples of IPSCs recorded from cells of the indicated genotypes. Munc13-1/2 DKO inhibitory neurons were identified after each experiment by detection of mIPSC events induced by application of α-latrotoxin. (F) Mean IPSC amplitudes measured in cells of the indicated genotypes. (G) mIPSC activity recorded in cells of the indicated genotypes. Pipette solution contained 140 mM KCl.