TABLE 3.

Comparison of questions proposed by the GUIDEnano approach to analyze quality of papers according to the K‐score (left column) and additional questions introduced in this work to assess sex/gender dimension in reported data (right column).

Questions from GUIDEnano K‐score approach	Questions used in this literature research
Is the test model given?*	Is the test model given and appropriately described?*
Is information given on the source/origin of the cell line?	Is information given on the source/origin of the animal model?
Are necessary information on test system properties, and on conditions of cultivation and maintenance given?	Are necessary information on test system properties, and on conditions of cultivation and maintenance given?
Is the method of administration given?*	Is the method of administration given?
Are duration of exposure as well as time‐points of observations explained?*	Are duration of exposure as well as time‐points of observations explained?
Were negative and positive controls included (where and when needed)?*	Were negative and positive controls included (where and when needed)?
Is the number of replicates (or complete repetitions of experiment) given?*	Is the number of replicates (or complete repetitions of experiment) given?
Are the study endpoint(s) and their method(s) of determination clearly described?*	Are the study endpoint(s) and their method(s) of determination clearly described?
Have the results been analyzed using statistical methods?*	Have the results been analyzed using statistical methods?
—	Were both female and male animals used?*
—	Were results from females and males analyzed separately?*
—	Were differences between females and males statistically analyzed?

Note: Questions marked with an asterisk (*) had to be answered positively.