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. Author manuscript; available in PMC: 2025 Sep 19.
Published in final edited form as: Addiction. 2022 Feb 1;117(6):1768–1777. doi: 10.1111/add.15795

TABLE 1.

Difference-in-difference estimates for past-month co-use of cigarettes and cannabis

Adjusted DID estimate
MCL aOR (95% CI) P_int RCL aOR (95% CI) P_int
Overall 1.087 (1.024, 1.155) 1.061 (0.955, 1.178)
Age (years)
 12–17 0.832 (0.764, 0.906) < 0.001 0.645 (0.513, 0.810) < 0.001
 18–25 0.966 (0.906, 1.029) 0.015 0.840 (0.733, 0.963) 0.014
 25–34 1.064 (0.976, 1.159) Ref. 1.076 (0.919, 1.261) Ref.
 35–49 1.153 (1.056, 1.258) 0.108 1.242 (1.049, 1.471) 0.190
 50+ 1.599 (1.391, 1.838) < 0.001 1.374 (1.028, 1.836) 0.120
F(4) = 25.754 (P < 0.001) F(4) = 8.421 (P < 0.001)
Gender
 Male 1.082 (1.013, 1.155) 0.662 1.031 (0.910, 1.168) 0.382
 Female 1.097 (1.022, 1.178) Ref. 1.112 (0.961, 1.286) Ref.
F(1) = 0.191 (P = 0.662) F(1) = 0.763 (P = 0.382)
Marital status
 Married 1.188 (1.074, 1.313) 0.001 1.240 (1.023, 1.504) 0.012
 Widowed/divorced/separated 1.305 (1.160, 1.469) < 0.001 1.212 (0.959, 1.531) 0.056
 Never married 1.023 (0.957, 1.093) Ref. 0.947 (0.836, 1.074) Ref.
F(2) = 12.347 (P < 0.001) F(2) = 3.958 (P = 0.019)
Income
 < $20 000 1.122 (1.040, 1.211) 0.382 1.160 (0.944, 1.425) 0.109
 $20 000–74 000 1.064 (0.986, 1.148) 0.646 1.129 (0.968, 1.317) 0.087
 ≥ $75 000 1.084 (1.007, 1.167) Ref. 0.956 (0.831, 1.099) Ref.
F(2) = 0.853 (P = 0.426) F(2) = 2.007 (P = 0.135)
Race/ethnicity
 Non-Hispanic white 1.106 (1.037, 1.180) Ref. 1.037 (0.915, 1.175) Ref.
 Non-Hispanic black 1.143 (1.024, 1.276) 0.563 1.165 (0.803, 1.690) 0.544
 Hispanic 0.973 (0.871, 1.088) 0.019 1.038 (0.834, 1.292) 0.993
 Non-Hispanic other 0.934 (0.814, 1.072) 0.015 1.240 (0.975, 1.578) 0.164
F(3) = 3.697 (P = 0.011) F(3) = 0.747 (P = 0.524)
Educational attainment
 Less than high school 1.026 (0.932, 1.130) 0.049 1.118 (0.860, 1.453) 0.400
 High school or equivalent 1.145 (1.057, 1.241) 0.816 1.043 (0.874, 1.244) 0.586
 Some college 1.055 (0.974, 1.144) 0.104 1.073 (0.919, 1.252) 0.453
 College graduate or above 1.160 (1.043, 1.291) Ref. 0.973 (0.791, 1.197) Ref.
F(3) = 2.642 (P = 0.048) F(3) = 0.287 (P = 0.835)

aOR = adjusted odds ratio; CI = confidence interval; DID = difference-in-difference; MCL = medical cannabis laws; P_int: P-value for the interaction term; RCL = recreational cannabis laws.

Adjusted analyses were adjusted for the other socio-demographic variables listed in the table.