Table 4. Effects of 2-week finasteride without restraint on behavioral outcomes.
Mean ± S.E.M. for % time in the open arm on the elevated plus maze (left) and % time immobile on the forced swim test (right) after 2-week administration of finasteride (FIN) or vehicle (VEH) without restraint to the indicated groups of wild-type mice. Left, sex and age of experimental animals, Top, group designations. Pub, pubertal. Each row represents a different comparison within the behavioral sub-group. No comparisons were significantly different (7–10 mice/group).
| Elevated plus maze Forced swim
test | ||||||
|---|---|---|---|---|---|---|
| Sex | VEH | FIN | P value | VEH | FIN | P value |
| Female pub | 36.1 ± 2.4 | 34.3 ± 1.4 | 0.53 | 57.2 ± 3.7 | 54.5 ± 1.8 | 0.58 |
| Male pub | 35.7 ± 2.6 | 36.5 ± 2.1 | 0.82 | 60.3 ± 4.7 | 66.9 ± 2.3 | 0.25 |
| Female adult | 31.0 ± 2.9 | 36.4 ± 2.4 | 0.18 | 59.2 ± 4.1 | 55.3 ± 2.4 | 0.44 |