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. 2025 Jan 22;24(9):100910. doi: 10.1016/j.mcpro.2025.100910

Fig. 2.

Fig. 2

Single-cell proteomics of aCMs.A, workflow of aCM isolation to single cell proteomics. B, representative images of aCMs in the dispensing capillary before sorting. C, Cell size comparison between aCM and iCM (aCMs=161 cells; iCMs=187 cells). D, proteome overlaps between aCMs and Day21 iCMs. E–G, radar plots comparing ClueGO enrichments in cellular components (E), biological processes (F), and pathways, in aCMs unique proteins (green), iCM unique proteins (orange), and the common aCM and iCM overlapping proteins (blue). H–J. UMAPs of individual aCM proteomes colored by the location isolated (H), two Leiden clusters (I), and protein count (J), in human1. K, cell size comparison between Leiden clusters 0 and 1 human1 aCMs. L-M. UMAPs of individual aCM proteomes colored by the location isolated (L), two Leiden clusters (M), and protein count (N), in human2. O, cell size comparison between Leiden clusters 0 and 1 human2 aCMs; p > 0.05, not significant by t test. P–R. ClueGO protein enrichments of cluster0 aCMs in cellular components (P), biological processes (Q), and pathways (R), compared to cluster1 aCMs in human1 (blue) and human2 (orange), respectively.