Table 2.
Analysis of influencing factors of intestinal barrier function impairment.
| Variable |
1Normal group n = 98 |
2Mild group n = 264 |
3Moderate group n = 259 |
4Severe group n = 120 |
F value | p value |
|---|---|---|---|---|---|---|
| DAO(U/L) | 7.05 ± 2.08d | 13.45 ± 5.49c | 18.63 ± 5.76b | 23.08 ± 6.82a | 161.13** | <0.01 |
| D-lac(mg/L) | 10.72 ± 2.98d | 13.02 ± 4.0c | 18.05 ± 3.02b | 20.03 ± 2.37a | 208.19** | <0.01 |
| LPS(U/L) | 8.73 ± 2.85d | 11.51 ± 4.15c | 15.09 ± 5.07b | 27.34 ± 6.65a | 316.33** | <0.01 |
| Age, years, x ± s | 70.17 ± 10.82a | 69.89 ± 11.64a | 66.27 ± 14.93b | 61.91 ± 17.38c | 9.92** | <0.01 |
| Sex [n(%)] | ||||||
| Male | 62(63.26) | 136(72.73) | 180(68.70) | 143(72.23) | 2.83 | 0.42 |
| Inflammatory biomarkers | ||||||
| WBC (×109/L) | 8.52 ± 4.25d | 9.95 ± 6.07c | 11.55 ± 6.11b | 13.62 ± 7.67a | 12.68** | <0.01 |
| NE (×109/L) | 6.81 ± 4.04d | 7.95 ± 4.88c | 9.73 ± 5.83a | 11.65 ± 7.19a | 15.63** | <0.01 |
| CRP (μg/mL) | 59.13 ± 52.09d | 77.07 ± 75.71c | 92.2 ± 77.79b | 117.27 ± 104.71a | 9.97** | <0.01 |
| PCT (ng/mL) | 2.32 ± 7.37 | 4.11 ± 10.51 | 5.77 ± 18.02 | 7.05 ± 14.07 | 2.24 | 0.08 |
| Nutritional status | ||||||
| Hb (g/L) | 90.21 ± 20. ×109/L 15 | 95.66 ± 21.10 | 97.31 ± 21.64 | 95.45 ± 22.52 | 2.15 | 0.09 |
| ALB (g/L) | 31.49 ± 4.51 | 32.11 ± 4.51 | 32.25 ± 3.67 | 31.52 ± 4.04 | 1.26 | 0.29 |
| PA (mg/dL) | 12.14 ± 5.55a | 12.08 ± 5.59a | 12.10 ± 5.42a | 10.41 ± 5.18b | 3.16* | 0.02 |
| RBP (mg/L) | 26.500 ± 14.133a | 21.316 ± 11.307b | 22.630 ± 12.911b | 21.568 ± 12.784b | 3.09* | 0.03 |
| LYM (×109/L) | 0.96 ± 0.48 | 1.06 ± 1.49 | 0.95 ± 0.58 | 0.95 ± 0.55 | 0.72 | 0.54 |
| PNI | 35.66 ± 7.06a | 35.60 ± 11.35a | 35.74 ± 8.14a | 33.15 ± 10.51b | 4.43** | <0.01 |
| Cytokines | ||||||
| IL-2 (pg/ml) | 1.22 ± 1.11 | 1.65 ± 2.92 | 1.59 ± 2.17 | 5.61 ± 25.72 | 1.43 | 0.24 |
| IL-4 (pg/ml) | 1.19 ± 0.90 | 1.68 ± 3.02 | 1.36 ± 1.29 | 1.11 ± 0.95 | 0.86 | 0.47 |
| IL-6 (pg/ml) | 55.37 ± 59.54d | 87.82 ± 247.72c | 253.09 ± 724.45b | 608.80 ± 1485.86a | 4.19** | <0.01 |
| IL-10 (pg/ml) | 11.62 ± 8.14 | 14.21 ± 21.10 | 42.13 ± 134.65 | 87.37 ± 358.95 | 1.67 | 0.18 |
| TNF-α (pg/ml) | 1.03 ± 1.15 | 1.22 ± 2.66 | 1.40 ± 1.69 | 0.67 ± 0.63 | 1.47 | 0.22 |
| IFN-γ (pg/ml) | 1.56 ± 1.57 | 1.60 ± 1.97 | 1.68 ± 1.84 | 1.08 ± 1.40 | 1.13 | 0.34 |
1
DAO, D-Lac, LPS: −−−.
2
DAO, D-Lac, LPS: + − −, − + −.
3
DAO, D-Lac, LPS: ++−, + − +.
4
DAO, D-Lac, LPS: +++; +, above the upper limit of the reference value range; −, within the reference value range.
a,b,c,dDisplay statistical differences between groups, if two groups have the same letter, their difference is statistically non-significant, if the different letters, their difference is statistically significant. **p<0.01; *p<0.05.